PRESENTATION 1: B-CELL LYMPHOMA GENE (BCL-2) (28/2)

Assalammualaikum and hello guys!!!

    On 28 of February, our class have presentation session with dr. Azran Azhim. Each groups were given a gene which we were assigned to make a research regarding the given gene. There are 15 groups which means there are 15 genes.

1. RLF
2. COL1A1
3. COL3A1
4. COL9A1
5. IL10
6. BRCA1
7. CD4
8. CD8
9. IL2
10. ALB
11. LCK
12. BCL2
13. ABO
14. OSM
15. NPPB

    From all of these we have learnt something new regarding the genes on what their functions, how they work and where can it be found. For this assignment, we're using blast we NCBI (National Center for Biotechnology Information Search database), BLAST (Basic Local Alignment Search Tool), and CLC apps As for our group, we got the BCL2 gene. So today, we're going to talk about our gene.

      We used human(Homo sapiens) as reference to make comparison between human and other 5 organism which are domestic guinea pig (cavia porcellus), domestic cat (Felis catus), chicken (Gallus gallus gallus), channel catfish (Ictalurus punctatus) and Rhesus monkey (Macaca mulatta).

        We used BLAST and CLC to find out their percentage of similarity between human  and other 5 organisms. 

From this table we can see that domestic guinea pig has the highest percentage similarity and channel catfish has the lowest percentage similarity with human regarding their BCL-2 gene.

        This figure shows the alignment tree which we create using CLC. From this figure we can see that rhesus monkey and human, and guniea pig and human are aligned near with each other as their percentage of similarity are the highest. guniea pig and human are aligned on different branch even though they have the highest percentage of similarity. It is because they come from different ancestor. 

Last but not least, we're going to talk about the functions of BCL-2 gene. 

TADAAA!!!!

That is all for our presentation session. Overall, every group have done their presentation well.